Vladimir Dragalin
Adaptive designs in dose-ranging clinical trials

Abstract: The overall goal of dose-ranging studies is to establish the existence, nature and extent of dose effect. Recently, a great effort has been made to investigate and develop designs and methods for efficient learning about dose response and more accurate and faster decision making on dose selection and improved labeling. The focus is on adaptive and model-based dose-ranging designs.

In this presentation, I will compare the performance of the different adaptive designs in learning about and estimating the dose response relationship. The evaluation of statistical operational characteristics of these new adaptive designs has been mainly done through comprehensive simulation studies. There is a need for new theoretical developments in the methodology for planning, monitoring and analysis for these sequential
designs

Marie Hušková
Sequential nonparametric estimation

Abstract: The talk will start with a short partial survey of results on sequential nonparametric procedures. Then it will focus on sequential confidence regions in location models as well as in nonparametric regression setup. Also, semiparametric sequential test procedures when a training sample is available will be covered. Both independent and dependent observations will be considered. Possibility of application of a suitable version of bootstrap method will be also discussed. Theoretical results will be accompanied by simulation study.

Moshe Pollak
The Shiryaev-Roberts Changepoint Detection Procedure in Retrospect - Theory and Practice

Abstract: A retrospective view of the Shiryaev-Roberts procedure is presented, placing it in a historical
context and describing its evolution into a powerful changepoint detection method.

Albert N. Shiryaev
Quickest detection of the spontaneous appearing effects - fifty years later

Abstract: We describe the very beginning (since 1959) of our work with A.N.Kolmogorov on the radiolocation problems which led us to the formulation and solution of the different versions of the quickest detection of the spontaneous appearing effects. A panorama of these results, their developments with numerous applications in different fields will be presented.